Cardiovascular Toxicology
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Overview

  • Recently we had an experience on a CSIR networked project (2003-07) "Predictive Medicine using Repeat and Single Nucleotide Polymorphism." Objective was to develop database on the status of "SNPs" and Repeat Polymorphism in the selected gene GSTM1 amongst Indian population and its association with disease.

  • Present work on Genetic polymorphism in metabolizing enzyme genes of control and diseased population and their association with the diseases. Studies are being conducted on GST polymorphism in Breast cancer & Gastric cancer patients in collaboration with SGPGIMS & in Chronic Myeloid Leukemia patients with CSMMU (KGMU), Lucknow respectively.

  • Training students from different universities such as Bundelkhand Univ., Amity Univ., Allahabad Agricultural institute Deemed Univ. Allahabad, APS Univ. Rewa, C.S.J.M. Univ. Kanpur, Gorakhpur Univ., & Meerut Univ. These students were given hands on Nucleic acid isolation, PCR, & RFLP, etc.

  Major activities:

  • Genotyping analysis in case control studies in particular cancer.

  • Cardiovascular studies in animals exposed to toxic compounds

Highlights of Research Activities:
Paper / Abstracts published:

  • Bajpai P, Tripathi AK, Agrawal D. Increased frequencies of Glutathione -S- Transferase (GSTM1 & GSTT1) null genotypes in Indian patients with Chronic Myeloid Leukemia. Leukemia Res. 31 (2007) 1359-1363.

  • Review article: The Indian genome variation database (IGVdb): a project overview Human Genetics 118, 1-11(2005).

Abstract presented at:

  • 18th Wonca World Conference 2007, 24 - 27 July 2007, held at Singapore. 

  • 4th ISGO International Conference Structural Genomics Oct 22-26, (2006). held at Beijing, China.

Abstract published at:

  • 12th Congress of EHA. 7th-10th June, 2007, held at Vienna. 

  • American Association of Cancer Research (AACR ) 97th Annual Meeting on 1-5 April,2006 held at Washington, DC. 

  • International Conference on Toxicology, Environmental and Occupational Health (ICTEOH) on 14-17 Nov., 2005 held at Lucknow.
Major Facilities available:

  • Grass Polygraph & UGO basile B.P. Recorder - 8006 instruments facility available for measurement of blood pressure/ heart rate, ECG, EEG, and neuromuscular transmission activity.

  • PCR, Refrigerated centrifuge, spectrophotometer, other instruments - required for genotyping analysis are available.

  Staff:
Dr. (Mrs.) Deepa Agrawal, Scientist F and Head
Dr. GSD Gupta, TO Gr III (6)
Mr. M D Rana, TO Gr III (6)

Project Staff:
Ms. Prachi Bajpai, SRF
Ms. Richa Chandra, Project Assistant II
Mr. A.K. Srivastava, Project Assistant I

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