Toxicogenomics & Predictive Toxicology
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  Major activities:

  • Mechanism of sporadic and pesticides induced Parkinson's disease and development of molecular fingerprints.

  • Development of biomarkers of toxic responses and assessment of contribution of genetic polymorphisms in the selected genes in toxicant mediated/induced diseases/disorders.

Highlights of Current Research:

  • Microarray and proteomics approaches to understand the molecular mechanism of sporadic and pesticides induced PD, to develop signature fingerprints/biomarkers for an early diagnosis and to establish the mechanism of caffeine/nicotine mediated neuroprotection.

  • Differential displays of qualitative and quantitative changes in genes/proteins present in unexposed and toxicant exposed tissues using microarray and proteomics approaches to develop molecular fingerprints.

  • Assessment of the involvement of secondary mediators in toxicant induced diseases and disorders.

  • Assessment of association of single nucleotide polymorphism (SNP) in toxicant responsive genes, tumor suppressor genes and genes involved in signal transduction in cancers and neurodegenerative diseases.

Major Facilities available:

  • Microarray Facility: Robotic Spotter, Hybridization Workstation and Scanner.

  • Proteomics Facility: 1D and 2D-Gel Electrophoresis Units, Electro-blotting Unit, Protein Sequencer etc.

  • Other Facilities: PCR, Gel Documentation System, Fluorimeter, Spectrophotometer etc.

  Staff:
Dr. M.P. Singh, Scientist C and Head

Project Staff:
Ms. Suman Patel, SRF (CSIR)
Mr. Abhai Kumar, SRF (CSIR)
Mr. Virendra Singh, SRF (CSIR) 
Mr. Ghanshyam Upadhyay, SRF (CSIR)
Ms. Seema Singh, JRF (UGC)
Mr. Anand Kumar Singh, JRF (CSIR)
Ms. Ashima Sinha, Project Assistant (ICMR)
Ms. Kavita Singh, Project Assistant (DBT)

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