Current R&D Activities:
Oxidative stress generally caused by the production of reactive oxygen species (ROS) has been reported in alloxan as well as streptozotocin induced diabetic rats and known to be an important mediator of hyperglycemia related complications. Research is being done to explore new chemical entities or herbal supplements to control hyperglycemia and its complications. Modulation of antioxidant responses, transcription factors, specific receptors during high glucose stress and its restoration by selected herbal extract is being explored in vivo and at cellular level. Some medicinal plants have been identified for their antihyperglycemic action and antioxidant potential. The plant extracts are being studied to see their in vitro inhibition potential for alpha-glucosidase and dipeptidyl peptidase (DPP IV).