Dr. Mahendra Pratap Singh
Scientist C
Toxicogenomics & Predictive Toxicology

Contact Information:
Email: singhmahendrapratap@rediffmail.com
Tel: +91-522 2613786/2627586 Ext. 337
Fax: +91-522-2628227, 2611547
Area of Specialization:
Toxicogenomics & Predictive Toxicology 
Biochemical Pharmacology

Current R&D Activities:
Molecular mechanism of Parkinson's disease and development of molecular fingerprints 
Parkinson's disease (PD), a progressive multi-factorial neurodegenerative disorder, is contributed by combination of age, genetic and environmental factors. Despite of extensive researches, complete mechanism and early diagnosis of PD are not yet completely established. Genomics and proteomics based approaches are used to understand the molecular mechanism of PD, develop signature fingerprints/biomarkers for an early diagnosis and mechanism involved in neuroprotection. Studies are being done to develop signature fingerprints/biomarkers, elucidate the mechanism of pesticide induced PD phenotype and nicotine and caffeine induced neuroprotection. 

Development of biomarkers of toxic responses and assessment of contribution of genetic polymorphism in toxicant induced diseases 
In this program the differential display of qualitative and quantitative changes in thousands of genes/proteins present in unexposed and toxicant exposed tissues are being studied using transcription profiling/proteomics. Involvement of nitric oxide and toxicant responsive genes in chemical induced cytotoxicity and transcription profiling in toxicant exposed animal tissues in presence or absence of protective agents are being done for understanding the mechanism of toxicity and its reversal. Additionally, single nucleotide polymorphism (SNP) in toxicant responsive genes, tumor suppressor genes and genes involved in signal transduction are being studied for establishing associations of single nucleotide polymorphism with susceptibility of toxicant induced diseases.

Partial List of Research Publications:
Click here for the list

 

Awards/Honours/ Distinctions:
  • Recipient of Merit/State Merit Scholarship at College Level.

  • Qualified National Eligibility Test (NET) for Junior Research Fellowship and Eligibility for Lectureship under Council of Scientific and Industrial Research (CSIR) fellowship schemes conducted jointly by University Grant Commission (UGC) and CSIR, India (1994).

  • Qualified Graduate Aptitude Test in Engineering (GATE) conducted by Indian Institute of Technology (IIT), Kanpur, India (1995).

  • Awarded Research Associateship from CSIR, New Delhi and Indian Council of Medical Research (ICMR), New Delhi, India.

  • Member, Editorial Board, Journal of Theoretical and Experimental Pharmacology.

  • Member, Editorial Board, Proteomics Insights.

  • Ad-hoc reviewer in many scientific journals that include, Indian Journal of Medical Research, Proceedings of the National Academy of Sciences, India (Section B- Biological Sciences), Current Pharmacogenomics, Frontiers in Biosciences, Expert Opinion on Drug Metabolism and Toxicology and Proteomics.