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Dr.
Mahendra Pratap Singh
Scientist C
Toxicogenomics & Predictive Toxicology
Contact Information:
Email: singhmahendrapratap@rediffmail.com
Tel: +91-522 2613786/2627586 Ext. 337
Fax: +91-522-2628227, 2611547 |
Area
of Specialization:
Toxicogenomics & Predictive Toxicology
Biochemical Pharmacology
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Current R&D
Activities:
Molecular mechanism of Parkinson's disease and development of molecular
fingerprints
Parkinson's disease (PD), a progressive multi-factorial neurodegenerative
disorder, is contributed by combination of age, genetic and environmental
factors. Despite of extensive researches, complete mechanism and early
diagnosis of PD are not yet completely established. Genomics and
proteomics based approaches are used to understand the molecular mechanism
of PD, develop signature fingerprints/biomarkers for an early diagnosis
and mechanism involved in neuroprotection. Studies are being done to
develop signature fingerprints/biomarkers, elucidate the mechanism of
pesticide induced PD phenotype and nicotine and caffeine induced
neuroprotection.
Development of biomarkers of toxic responses and assessment of
contribution of genetic polymorphism in toxicant induced diseases
In this
program the differential display of qualitative and quantitative changes
in thousands of genes/proteins present in unexposed and toxicant exposed
tissues are being studied using transcription profiling/proteomics.
Involvement of nitric oxide and toxicant responsive genes in chemical
induced cytotoxicity and transcription profiling in toxicant exposed
animal tissues in presence or absence of protective agents are being done
for understanding the mechanism of toxicity and its reversal.
Additionally, single nucleotide polymorphism (SNP) in toxicant responsive
genes, tumor suppressor genes and genes involved in signal transduction
are being studied for establishing associations of single nucleotide
polymorphism with susceptibility of toxicant induced diseases.
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Partial List of Research
Publications:
Click here for the list
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Awards/Honours/
Distinctions:
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Recipient
of Merit/State Merit Scholarship at College Level.
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Qualified
National Eligibility Test (NET) for Junior Research Fellowship and
Eligibility for Lectureship under Council of Scientific and Industrial
Research (CSIR) fellowship schemes conducted jointly by University
Grant Commission (UGC) and CSIR, India (1994).
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Qualified
Graduate Aptitude Test in Engineering (GATE) conducted by Indian
Institute of Technology (IIT), Kanpur, India (1995).
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Awarded
Research Associateship from CSIR, New Delhi and Indian Council of
Medical Research (ICMR), New Delhi, India.
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Member,
Editorial Board, Journal of Theoretical and Experimental Pharmacology.
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Member, Editorial Board, Proteomics Insights.
- Ad-hoc reviewer in many scientific
journals that include, Indian Journal of Medical Research, Proceedings
of the National Academy of Sciences, India (Section B- Biological
Sciences), Current Pharmacogenomics, Frontiers in Biosciences, Expert
Opinion on Drug Metabolism and Toxicology and Proteomics.
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